This absolutely up-to-date and revised moment variation tackle in particular the various major advances made in our realizing of the pathophysiology of penile melanoma together with dialogue of the suspected function of the human papilloma virus in penile carcinogenesis. equally, the molecular pathways implicated in precancerous and penile melanoma can be mentioned as those are the current pursuits of novel healing ways to this disorder. The textual content info the new nationwide and overseas diagnostic and therapy guidance which have been built through either the nationwide accomplished melanoma community© and the eu Urological organization setting up facts established criteria upon which the care of penile melanoma might be established. The textual content additionally covers major advances made within the diagnostic and healing method of either basic tumors and inguinal nodal metastases caused by penile melanoma reminiscent of penile sparing surgical procedure and minimally invasive inguinal lymph node surgical procedure. The textual content will equally highlights the development in melanoma particular consequence within the administration of loco-regionally complicated (N2/3) penile melanoma controlled via prematurely systemic chemotherapy by way of consolidative surgical procedure in correctly chosen sufferers in line with fresh potential part II info. It additionally covers the position of radiotherapy within the administration of penile melanoma for either basic tumors and/or at websites of neighborhood or far away metastases. ultimately, a few of the novel systemic methods being devised within the administration of complicated penile melanoma in addition to a few upcoming foreign trials quickly to be opened which most probably will re-define the current healing methods to penile melanoma are discussed.